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Arginine-vasopressin AVP plays a critical role in the regulation of offensive aggression and social status in mammals. AVP is found in an extensive neural network in the brain. Here, we discuss the role of AVP in the regulation of aggression in the limbic system with an emphasis on the critical role of hypothalamic AVP in the control of aggression. In males, activation of AVP V1a receptors V1aRs in the hypothalamus stimulates offensive aggression, while in females activation of V1aRs inhibits aggression.
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