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Over the years one of the most perplexing concerns expressed in the DES community has been whether DES exposure affected the neurological system and sexual differentiation. Our readers are aware of physical changes, such as the T-shaped uterus, the higher risk for breast cancer in mothers and daughters, and the risk for clear cell cancer in daughters. Experiments with mice show effects on the reproductive system that also appear in DES Daughters. However, reports on possible neurological effects on humans have not come from experiments but involve analyses of existing factors. Here, some of the difficulties in getting a valid study are caused by a wide spread in the DES dosages mothers got, in the time in pregnancy when they got it, and for how long they took it.
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Gender, Sex, Sexuality and DES-Exposure: A Research Study | DES Action USA

How has your exposure to DES shaped your understanding of gender, sex, and sexuality? Most members of the DESexposed second generation would have reached puberty between and , a time of both very strong societal ideas about femininity and masculinity, as well as increasing resistance to expectations about what it means to be a woman or man. New ideas about sex hormones and techniques of genital surgery also emerged during this time period, shaping various fields of intersex and transgender health. The third generation of DES-exposed people is likely to have been born anytime between and now, experiencing life in a world of both rigid and fluid ideas about gender, sex and sexuality. How can the stories of this community help us to better understand the historical ongoing health, advocacy, and research needs of LGBTIQ and gender non-conforming DESexposed people? We will conduct interviews by phone and video conference, recording these with permission. We will anonymize everyone who shares their story in order to protect privacy.
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Even if, as the saying goes, the brain is a woman's most important sex organ, we can't deny the role our bodies play—especially as we get older. Satisfying sex depends on several things: presence of desire, arousal, absence of pain, and an ability to reach orgasm. After menopause, libido declines, and changes in our bodies can make it difficult to get aroused, painful to have intercourse, and impossible to climax. It's little wonder that many women become dissatisfied with sex, and some avoid intimacy entirely.
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